[Download PDF]
Education
The University of Chicago
Ph.D., Evolutionary Biology, 2013
Cornell University
BA summa cum laude, College Scholar in Organismal Biology, 2004
Research experience
University of North Carolina at Chapel Hill
Biology Department and Lineberger Comprehensive Cancer Center, 2013 – present
Postdoctoral fellow with Bob Goldstein
Stanford University
Hopkins Marine Station and Biology Department, 2010 – 2013
Graduate student with Christopher Lowe
The University of Chicago
Committee on Evolutionary Biology, 2007 – 2010
Graduate student with Christopher Lowe
The University of Louisville
Department of Biochemistry and Molecular Biology, 2004 – 2007
Research technician with Ronald Gregg
Cornell University
Department of Ecology and Evolutionary Biology, 2003 – 2004
Undergraduate researcher with David Winkler
Honors and awards
Postdoctoral Fellowship Award, 2016 – 2018
American Cancer Society
Ruth L. Kirschstein Postdoctoral National Research Service Award, 2015 –2016
National Institute of General Medical Sciences
Integrated Training in Cancer Model Systems Postdoctoral Fellowship, 2013 – 2015
University of North Carolina Lineberger Comprehensive Cancer Center
Earl H. and Ethel M. Myers Oceanographic and Marine Biology Trust Award, 2012
Ruth L. Kirschstein Predoctoral National Research Service Award, 2011 – 2013
National Institute of Neurological Disorders and Stroke
Frank R. Lillie Fellowship, 2009
Marine Biological Laboratory
Hinds Fund Research Award, 2009
The University of Chicago
Hughes Summer Research Award, 2003
Cornell University
College Scholar, 2001 – 2004
Cornell University
Publications
Gordon KL*, Payne SG*, Linden-High LM*, Pani AM, Goldstein B, Hubbard JA, Sherwood DR. (in press) Ectopic germ cells can induce niche-like enwrapment by body wall muscle. Current Biology. Preprint available at: https://dx.doi.org/10.2139/ssrn.3295646
Pani AM, Goldstein B (2018) Direct visualization of a native Wnt in vivo reveals that a long-range Wnt gradient forms by extracellular dispersal. eLife 7:e38325 DOI: 10.7554/eLife.38325. PDF
Heppert JK, Pani AM, Roberts AM, Dickinson DJ, Goldstein B (2018) A CRISPR tagging-based screen reveals localized players in Wnt-directed asymmetric cell division. Genetics 208: 1147-1164. PDF
Darras S, Fritzenwanker J, Uhlinger K, Farrelly E, Pani AM, Hurley I, Norris R, Osowitz M, Terasaki M, Wu M, Aronowicz J, Kirschner M, Gerhart J, Lowe CJ (2018) Anteroposterior patterning by early canonical Wnt signaling during hemichordate development. PLoS Biol 16: e2003698. PDF
Naegeli KM, Hastie E, Garde A, Wang Z, Keeley DP, Gordon KL, Pani AM, Kelley LC, Morrissey M, Chi Q, Goldstein B, Sherwood DR (2017) Cell invasion in vivo via rapid exocytosis of a transient lysosome-derived membrane domain. Dev Cell 43: 403-417.
Linden LM, Gordon KL, Pani AM, Payne SG, Garde A, Burkholder D, Chi Q, Goldstein B, Sherwood DR (2017) Identification of regulators of germ stem cell enwrapment by its niche in C. elegans. Dev Biol 429: 271-284. PDF
Heppert JK, Dickinson DJ, Pani AM, Higgins CD, Steward A, Ahringer J, Kuhn JR, Goldstein B (2016) Comparative assessment of fluorescent proteins for in vivo imaging in an animal model system. Mol Biol Cell 27: 3385-3394. Pubmed Central
Marston DJ*, Higgins CD*, Peters KA, Cupp TD, Dickinson DJ, Pani AM, Moore RP, Cox AH, Kiehart DP, Goldstein B (2016) MRCK-1 drives apical constriction in C. elegans by linking developmental patterning to force generation. Curr Biol 26: 2079-2089. PDF
Yao Y, Minor PJ, Zhao YT, Jeong Y, Pani AM, King AN, Symmons O, Gan L, Cardoso WV, Spitz F, Lowe CJ, Epstein DJ (2016) Cis-regulatory architecture of a brain signaling center predates the origin of chordates. Nat Genet 48: 575-580. Pubmed Central
Simakov O, Kawashima T, Marletaz F, Jenkins J, Koyanagi R, et. al. 23 of 52 authors (2015) Hemichordate genomes and deuterostome origins. Nature, 527: 459-465. PDF
Highlighted by – Dunn CW (2015) Genomics: Acorn worms in a nutshell. Nature 527: 448-449.
Dickinson DJ, Pani AM, Heppert J, Higgins CD, Goldstein B (2015) Streamlined genome engineering with a self-excising drug selection cassette. Genetics 200: 1035-1049. PDF
Pani AM, Mullarkey E*, Aronowicz J*, Assimacopoulos S, Grove EA, Lowe CJ (2012) Ancient deuterostome origins of vertebrate brain signalling centres. Nature 483: 289-294. Pubmed Central
Highlighted by – Gee H (2012) Developmental biology: a brainy background. Nature 483: 280.
Lowe CJ, Pani AM (2011) Animal evolution: a soap opera of unremarkable worms. Curr Biol 21: 151-153. PDF
Sobreira TJP, Marlétaz F, Simões-Costa M, Schechtman D, Pereira AC, Brunet F, Sweeney S, Pani A, Aronowicz J, Lowe CJ, Davidson B, Laudet V, Bronner M, de Oliveira PSL, Schubert M, Xavier-Neto J (2010) Structural shifts of aldehyde dehydrogenase enzymes were instrumental for the early evolution of retinoid-dependent axial patterning in metazoans. Proc Natl Acad Sci USA 108: 226-231. PDF
Pani AM, Hobart HH, Morris CA, Mervis CB, Bray-Ward P, Kimberley KW, Rios CM, Clark RC, Gulbronson MD, Gowans GC, Gregg RG (2010) Genome rearrangements detected by SNP microarrays in individuals with intellectual disability referred with possible Williams syndrome. PLoS One 5: e12349. PDF
Morris CA, Pani AM, Mervis CB, Rios CM, Kistler DJ, Gregg RG. (2010) Alpha-1-Antitrypsin deficiency alleles are associated with joint dislocation and scoliosis in Williams syndrome. Am J Med Genet Part C Semin Med Genet 154C; 299-306. Pubmed Central
Hobart HH, Morris CA, Mervis CB, Pani AM, Kistler DJ, Rios CM, Kimberley KW, Gregg RG, Bray-Ward P (2010) Inversion of the Williams syndrome region is a common polymorphism found more frequently in parents of children with Williams syndrome. Am J Med Genet Part C Semin Med Genet 154C: 220-228. Pubmed Central
Marshall C*, Young E*, Pani AM, Morris C, Freckmann M-L, Lacassie Y, Howard C, Fitzgerald KK, Peippo M, Morris CA, Shane K, Priolo M, Morimoto M, Kondo I, Manquoqlu E, Berker-Karauzum S, Edery P, Hobart HH, Mervis CB, Zuffardi O, Reymond A, Kaplan P, Tassabehji M, Gregg RG, Scherer SW, Osborne LR. (2008) Infantile spasms is associated with deletion of the MAGI2 gene on chromosome 7q11.23-q21.11. Am J Hum Genet, 83: 106-111. PDF
* equal contributions
Service
North Carolina Technology in Education Symposium, 2018
Assisted with microscopy workshop at statewide conference for public school teachers.
DIY microscope workshops for public school teachers, 2016 - 2018
Assisted with workshops showing public school teachers how to build and utilize DIY $10 microscopes for use in elementary schools. See http://goldsteinlab.weebly.com/diymicroscopeworkshops.html
Hopkins Marine Station Science Open Houses, 2011, 2012
Discussed marine biology research, conservation, and science careers with visitors of all ages at public open houses at Hopkins Marine Station adjacent to the Monterey Bay Aquarium.
Professional Associations
Society for Developmental Biology
American Society for Cell Biology
Teaching
The University of Chicago
Biological Systems, 2010
Teaching assistant
The University of Chicago
Molecular Approaches in Zoology, 2009
Teaching assistant
Selected conference presentations
Pani AM, Goldstein B (Upcoming, 2018, December) Direct visualization of a native Wnt in vivo reveals that a long-range Wnt gradient forms by free, extracellular dispersal. Minisymposium oral presentation, ASCB | EMBO Annual Meeting, San Diego, CA.
Pani AM, Goldstein B (2018, August) Direct visualization of a native Wnt in vivo reveals that a long-range Wnt gradient forms by free, extracellular dispersal. Oral presentation, Santa Cruz Developmental Biology Meeting, Santa Cruz, CA.
Pani AM, Goldstein B (2018, July) Direct visualization of a native Wnt in vivo reveals that a long-range Wnt gradient forms by free, extracellular dispersal. Poster presentation, Society for Developmental Biology Annual Meeting, Portland, OR.
Pani AM, Goldstein B (2018, June) Direct visualization of a native Wnt in vivo reveals that a long-range Wnt gradient forms by free, extracellular dispersal. Oral presentation, Gordon Research Conference on Cell Polarity Signaling, Mount Snow, VT.
Pani AM, Heppert JK, Goldstein B (2017, June) Investigating Wnt movement and gradient formation using live imaging of a natively tagged Wnt. Poster presentation, Gordon Research Conference on Developmental Biology, Mount Holyoke College, MA.
Pani AM, Heppert JK, Goldstein B (2016, August) Investigating mechanisms for Wnt movement and gradient formation using live imaging of an endogenous Wnt. Poster presentation, Santa Cruz Developmental Biology Meeting, Santa Cruz, CA.
Pani AM, Mullarkey E, Aronowicz J, Assimacopoulos S, Grove EA, Lowe CJ (2013, January) Ancient evolutionary origins of vertebrate brain signaling center genetic programs. Poster presentation, RIKEN Center for Developmental Biology Annual Symposium, Kobe, Japan.
Pani AM, Assimacopoulos S, Mullarkey E, Aronowicz J, Grove EA, Lowe CJ (2009, July) Signaling center-like genetic programs in hemichordates and the origins of axial patterning mechanisms during vertebrate brain evolution. Poster presentation, Society for Developmental Biology Annual Meeting, San Francisco, CA.
Morris CA, Pani AM, John A, Rios C, Kimberley KW, Hobart HH, Gregg RG, Mervis CB (2007). Mechanisms of facial dysmorphogenesis in Williams syndrome: Combination of haploinsufficiency of ELN and GTF2IRD1 genes plus the epigenetic effects of age and hypotonia. Oral presentation, David W. Smith Workshop on Malformations and Morphogenesis, Williamsburg, VA.
Pani AM, Hobart HH, Rios CM, Kimberley KW, Mervis CB, Morris CA, Gregg RG (2007, March). Identification and precise characterization of chromosomal copy number abnormalities in individuals with undiagnosed genomic disorders or rearrangements using high-resolution SNP microarrays. Poster presentation, American College of Medical Genetics Annual Meeting, Nashville, TN.
Education
The University of Chicago
Ph.D., Evolutionary Biology, 2013
Cornell University
BA summa cum laude, College Scholar in Organismal Biology, 2004
Research experience
University of North Carolina at Chapel Hill
Biology Department and Lineberger Comprehensive Cancer Center, 2013 – present
Postdoctoral fellow with Bob Goldstein
Stanford University
Hopkins Marine Station and Biology Department, 2010 – 2013
Graduate student with Christopher Lowe
The University of Chicago
Committee on Evolutionary Biology, 2007 – 2010
Graduate student with Christopher Lowe
The University of Louisville
Department of Biochemistry and Molecular Biology, 2004 – 2007
Research technician with Ronald Gregg
Cornell University
Department of Ecology and Evolutionary Biology, 2003 – 2004
Undergraduate researcher with David Winkler
Honors and awards
Postdoctoral Fellowship Award, 2016 – 2018
American Cancer Society
Ruth L. Kirschstein Postdoctoral National Research Service Award, 2015 –2016
National Institute of General Medical Sciences
Integrated Training in Cancer Model Systems Postdoctoral Fellowship, 2013 – 2015
University of North Carolina Lineberger Comprehensive Cancer Center
Earl H. and Ethel M. Myers Oceanographic and Marine Biology Trust Award, 2012
Ruth L. Kirschstein Predoctoral National Research Service Award, 2011 – 2013
National Institute of Neurological Disorders and Stroke
Frank R. Lillie Fellowship, 2009
Marine Biological Laboratory
Hinds Fund Research Award, 2009
The University of Chicago
Hughes Summer Research Award, 2003
Cornell University
College Scholar, 2001 – 2004
Cornell University
Publications
Gordon KL*, Payne SG*, Linden-High LM*, Pani AM, Goldstein B, Hubbard JA, Sherwood DR. (in press) Ectopic germ cells can induce niche-like enwrapment by body wall muscle. Current Biology. Preprint available at: https://dx.doi.org/10.2139/ssrn.3295646
Pani AM, Goldstein B (2018) Direct visualization of a native Wnt in vivo reveals that a long-range Wnt gradient forms by extracellular dispersal. eLife 7:e38325 DOI: 10.7554/eLife.38325. PDF
Heppert JK, Pani AM, Roberts AM, Dickinson DJ, Goldstein B (2018) A CRISPR tagging-based screen reveals localized players in Wnt-directed asymmetric cell division. Genetics 208: 1147-1164. PDF
Darras S, Fritzenwanker J, Uhlinger K, Farrelly E, Pani AM, Hurley I, Norris R, Osowitz M, Terasaki M, Wu M, Aronowicz J, Kirschner M, Gerhart J, Lowe CJ (2018) Anteroposterior patterning by early canonical Wnt signaling during hemichordate development. PLoS Biol 16: e2003698. PDF
Naegeli KM, Hastie E, Garde A, Wang Z, Keeley DP, Gordon KL, Pani AM, Kelley LC, Morrissey M, Chi Q, Goldstein B, Sherwood DR (2017) Cell invasion in vivo via rapid exocytosis of a transient lysosome-derived membrane domain. Dev Cell 43: 403-417.
Linden LM, Gordon KL, Pani AM, Payne SG, Garde A, Burkholder D, Chi Q, Goldstein B, Sherwood DR (2017) Identification of regulators of germ stem cell enwrapment by its niche in C. elegans. Dev Biol 429: 271-284. PDF
Heppert JK, Dickinson DJ, Pani AM, Higgins CD, Steward A, Ahringer J, Kuhn JR, Goldstein B (2016) Comparative assessment of fluorescent proteins for in vivo imaging in an animal model system. Mol Biol Cell 27: 3385-3394. Pubmed Central
Marston DJ*, Higgins CD*, Peters KA, Cupp TD, Dickinson DJ, Pani AM, Moore RP, Cox AH, Kiehart DP, Goldstein B (2016) MRCK-1 drives apical constriction in C. elegans by linking developmental patterning to force generation. Curr Biol 26: 2079-2089. PDF
Yao Y, Minor PJ, Zhao YT, Jeong Y, Pani AM, King AN, Symmons O, Gan L, Cardoso WV, Spitz F, Lowe CJ, Epstein DJ (2016) Cis-regulatory architecture of a brain signaling center predates the origin of chordates. Nat Genet 48: 575-580. Pubmed Central
Simakov O, Kawashima T, Marletaz F, Jenkins J, Koyanagi R, et. al. 23 of 52 authors (2015) Hemichordate genomes and deuterostome origins. Nature, 527: 459-465. PDF
Highlighted by – Dunn CW (2015) Genomics: Acorn worms in a nutshell. Nature 527: 448-449.
Dickinson DJ, Pani AM, Heppert J, Higgins CD, Goldstein B (2015) Streamlined genome engineering with a self-excising drug selection cassette. Genetics 200: 1035-1049. PDF
Pani AM, Mullarkey E*, Aronowicz J*, Assimacopoulos S, Grove EA, Lowe CJ (2012) Ancient deuterostome origins of vertebrate brain signalling centres. Nature 483: 289-294. Pubmed Central
Highlighted by – Gee H (2012) Developmental biology: a brainy background. Nature 483: 280.
Lowe CJ, Pani AM (2011) Animal evolution: a soap opera of unremarkable worms. Curr Biol 21: 151-153. PDF
Sobreira TJP, Marlétaz F, Simões-Costa M, Schechtman D, Pereira AC, Brunet F, Sweeney S, Pani A, Aronowicz J, Lowe CJ, Davidson B, Laudet V, Bronner M, de Oliveira PSL, Schubert M, Xavier-Neto J (2010) Structural shifts of aldehyde dehydrogenase enzymes were instrumental for the early evolution of retinoid-dependent axial patterning in metazoans. Proc Natl Acad Sci USA 108: 226-231. PDF
Pani AM, Hobart HH, Morris CA, Mervis CB, Bray-Ward P, Kimberley KW, Rios CM, Clark RC, Gulbronson MD, Gowans GC, Gregg RG (2010) Genome rearrangements detected by SNP microarrays in individuals with intellectual disability referred with possible Williams syndrome. PLoS One 5: e12349. PDF
Morris CA, Pani AM, Mervis CB, Rios CM, Kistler DJ, Gregg RG. (2010) Alpha-1-Antitrypsin deficiency alleles are associated with joint dislocation and scoliosis in Williams syndrome. Am J Med Genet Part C Semin Med Genet 154C; 299-306. Pubmed Central
Hobart HH, Morris CA, Mervis CB, Pani AM, Kistler DJ, Rios CM, Kimberley KW, Gregg RG, Bray-Ward P (2010) Inversion of the Williams syndrome region is a common polymorphism found more frequently in parents of children with Williams syndrome. Am J Med Genet Part C Semin Med Genet 154C: 220-228. Pubmed Central
Marshall C*, Young E*, Pani AM, Morris C, Freckmann M-L, Lacassie Y, Howard C, Fitzgerald KK, Peippo M, Morris CA, Shane K, Priolo M, Morimoto M, Kondo I, Manquoqlu E, Berker-Karauzum S, Edery P, Hobart HH, Mervis CB, Zuffardi O, Reymond A, Kaplan P, Tassabehji M, Gregg RG, Scherer SW, Osborne LR. (2008) Infantile spasms is associated with deletion of the MAGI2 gene on chromosome 7q11.23-q21.11. Am J Hum Genet, 83: 106-111. PDF
* equal contributions
Service
North Carolina Technology in Education Symposium, 2018
Assisted with microscopy workshop at statewide conference for public school teachers.
DIY microscope workshops for public school teachers, 2016 - 2018
Assisted with workshops showing public school teachers how to build and utilize DIY $10 microscopes for use in elementary schools. See http://goldsteinlab.weebly.com/diymicroscopeworkshops.html
Hopkins Marine Station Science Open Houses, 2011, 2012
Discussed marine biology research, conservation, and science careers with visitors of all ages at public open houses at Hopkins Marine Station adjacent to the Monterey Bay Aquarium.
Professional Associations
Society for Developmental Biology
American Society for Cell Biology
Teaching
The University of Chicago
Biological Systems, 2010
Teaching assistant
The University of Chicago
Molecular Approaches in Zoology, 2009
Teaching assistant
Selected conference presentations
Pani AM, Goldstein B (Upcoming, 2018, December) Direct visualization of a native Wnt in vivo reveals that a long-range Wnt gradient forms by free, extracellular dispersal. Minisymposium oral presentation, ASCB | EMBO Annual Meeting, San Diego, CA.
Pani AM, Goldstein B (2018, August) Direct visualization of a native Wnt in vivo reveals that a long-range Wnt gradient forms by free, extracellular dispersal. Oral presentation, Santa Cruz Developmental Biology Meeting, Santa Cruz, CA.
Pani AM, Goldstein B (2018, July) Direct visualization of a native Wnt in vivo reveals that a long-range Wnt gradient forms by free, extracellular dispersal. Poster presentation, Society for Developmental Biology Annual Meeting, Portland, OR.
Pani AM, Goldstein B (2018, June) Direct visualization of a native Wnt in vivo reveals that a long-range Wnt gradient forms by free, extracellular dispersal. Oral presentation, Gordon Research Conference on Cell Polarity Signaling, Mount Snow, VT.
Pani AM, Heppert JK, Goldstein B (2017, June) Investigating Wnt movement and gradient formation using live imaging of a natively tagged Wnt. Poster presentation, Gordon Research Conference on Developmental Biology, Mount Holyoke College, MA.
Pani AM, Heppert JK, Goldstein B (2016, August) Investigating mechanisms for Wnt movement and gradient formation using live imaging of an endogenous Wnt. Poster presentation, Santa Cruz Developmental Biology Meeting, Santa Cruz, CA.
Pani AM, Mullarkey E, Aronowicz J, Assimacopoulos S, Grove EA, Lowe CJ (2013, January) Ancient evolutionary origins of vertebrate brain signaling center genetic programs. Poster presentation, RIKEN Center for Developmental Biology Annual Symposium, Kobe, Japan.
Pani AM, Assimacopoulos S, Mullarkey E, Aronowicz J, Grove EA, Lowe CJ (2009, July) Signaling center-like genetic programs in hemichordates and the origins of axial patterning mechanisms during vertebrate brain evolution. Poster presentation, Society for Developmental Biology Annual Meeting, San Francisco, CA.
Morris CA, Pani AM, John A, Rios C, Kimberley KW, Hobart HH, Gregg RG, Mervis CB (2007). Mechanisms of facial dysmorphogenesis in Williams syndrome: Combination of haploinsufficiency of ELN and GTF2IRD1 genes plus the epigenetic effects of age and hypotonia. Oral presentation, David W. Smith Workshop on Malformations and Morphogenesis, Williamsburg, VA.
Pani AM, Hobart HH, Rios CM, Kimberley KW, Mervis CB, Morris CA, Gregg RG (2007, March). Identification and precise characterization of chromosomal copy number abnormalities in individuals with undiagnosed genomic disorders or rearrangements using high-resolution SNP microarrays. Poster presentation, American College of Medical Genetics Annual Meeting, Nashville, TN.